Ara-290 1208243-50-8

Ara-290 (CAS No. 1208243-50-8) is a synthetic 11–amino acid peptide derived from the helix-B surface peptide of erythropoietin (EPO). Designed to selectively activate the EPOR–CD131 heteroreceptor, Ara-290 has become a leading molecule in neuroprotection, inflammation regulation, and tissue repair research.

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Product Description

Key Features & Advantages

Targeted EPOR–CD131 Activation

Ara-290 specifically binds the innate repair receptor (IRR), enabling researchers to study EPO-derived tissue repair mechanisms without hematopoietic side effects.

Potent Anti-inflammatory Properties

Research demonstrates significant reduction of pro-inflammatory cytokines, supporting investigations into chronic inflammation, autoimmune response, and metabolic disorders.

Neuroprotective & Neuropathic Pain Modulation

Ara-290 has shown strong potential in reducing nerve inflammation and restoring nerve function in neuropathic pain models, making it valuable in neurobiology studies.

Supports Tissue Repair & Organ Protection

Studies highlight its ability to reduce cellular stress, enhance microvascular function, and promote healing following ischemic injury, trauma, or metabolic dysfunction.

Non-erythropoietic Profile

Ara-290 provides the protective benefits of EPO signaling without affecting red blood cell production, enabling safer, targeted research applications.

High Stability & Excellent Research Consistency

Lyophilized, purified form ensures consistent biological activity in cellular and animal model experiments.

Molecular Details

Parameter	Description
CAS Number	1208243-50-8
Product Name	Ara-290
Peptide Origin	EPO-derived helix-B surface peptide (HBSP)
Amino Acid Length	11 amino acids
Appearance	White to off-white lyophilized powder
Storage	–20°C, avoid light and moisture

Specifications & Packaging

Specification	Details
Purity	≥98% (HPLC)
Form	Lyophilized powder
Vial Sizes	1 mg, 5 mg, 10 mg (custom options available)
Packaging	Sterile sealed vials, moisture-resistant packaging
Shelf Life	24 months under recommended storage

Applications in Research and Development

1. Neuroprotection & Neuropathic Pain Research

Used in studying nerve injury, diabetic neuropathy, and inflammatory neuropathies due to its ability to modulate nerve inflammation and repair pathways.

2. Anti-inflammatory & Immunomodulation Studies

A key molecule for evaluating cytokine regulation, immune response modulation, and autoimmune condition models.

3. Tissue Repair & Regeneration

Supports research on organ protection, ischemia-reperfusion injury, wound healing, and microvascular recovery.

4. Metabolic & Chronic Disease Research

Explored for its protective role in metabolic dysfunction, including diabetes-associated tissue damage.

5. EPO-Derivative Pathway Investigation

Ideal for analyzing non-erythropoietic EPO signaling through the EPOR-CD131 receptor complex.

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