Product Description
EPO binds to the erythropoietin receptor (EPOR) on erythroid progenitor cells, stimulating proliferation, differentiation, and maturation of red blood cells. It is the gold standard molecule for modeling anemia and hypoxia in research.
Beyond hematopoiesis, EPO demonstrates cytoprotective effects in various tissues, including neuronal, cardiac, and renal tissues, making it valuable for studies on ischemia-reperfusion injury, neuroprotection, and organ regeneration.
EPO is widely used as a reference molecule in preclinical studies of anemia, chronic kidney disease, chemotherapy-induced cytopenia, and hypoxia-related conditions.
Through EPOR activation, EPO triggers downstream JAK2/STAT5, PI3K/Akt, and MAPK pathways, allowing researchers to study signal transduction, cell survival, and proliferation.
Recombinant EPO is supplied as highly purified, biologically active protein, suitable for in vitro and in vivo experimental applications.
| Parameter | Description |
| CAS Number | 11096-26-7 |
| Product Name | Erythropoietin (EPO) |
| Molecular Formula | C₈₃₀H₁₃₃₇N₂₃₁O₂₄₆S₅ |
| Molecular Weight | ~30,400 Da (glycosylated form) |
| Peptide Length | 165 amino acids (glycoprotein) |
| Appearance | White to off-white lyophilized powder |
| Storage | –20°C, protected from light and moisture |
| Specification | Option / Value |
| Purity | ≥95% (HPLC or SDS-PAGE) |
| Form | Lyophilized protein powder |
| Vial Sizes | Typically 1 mg, 5 mg, 10 mg (custom packaging available) |
| Packaging | Sterile sealed vials, moisture-resistant, temperature-controlled |
| Shelf Life | 12–24 months under recommended storage conditions |
1. Hematology & Anemia Models: Used to investigate erythropoiesis, red blood cell maturation, and anemia therapeutics.
2. Hypoxia & Oxygenation Studies: Models cellular response to hypoxic stress, including tissue adaptation and erythropoietic signaling.
3. Organ Protection & Regeneration: Explored for neuroprotection, cardioprotection, and renal protection in preclinical models.
4. Signal Transduction Research: EPO serves as a tool for studying JAK2/STAT5, PI3K/Akt, and MAPK pathways in hematopoietic and non-hematopoietic cells.
5. Preclinical Drug Development: Used as a reference in developing erythropoiesis-stimulating agents (ESAs) or tissue-protective peptide analogs.
