Follistatin 80449-31-6

Follistatin (CAS No. 80449-31-6) is a naturally occurring glycoprotein and potent myostatin-binding peptide that regulates muscle growth, tissue regeneration, and reproductive hormone activity. By binding and inhibiting members of the TGF-β superfamily such as myostatin and activin, Follistatin promotes skeletal muscle hypertrophy and enhances cellular proliferation.

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Product Description

Key Features & Advantages

Powerful Myostatin Inhibition

Follistatin binds to myostatin with high affinity, preventing its inhibitory effect on skeletal muscle growth, making it a key tool for studying muscle hypertrophy and sarcopenia models.

Supports Tissue Repair & Regeneration

Beyond muscle growth, Follistatin promotes cell proliferation, tissue repair, and recovery in various organ systems, including liver, heart, and skeletal muscle.

Modulates Reproductive Hormones

By binding activin, Follistatin regulates FSH (follicle-stimulating hormone) secretion, making it useful in reproductive biology studies.

Anti-Fibrotic & Metabolic Effects

Research suggests Follistatin can reduce fibrosis and improve metabolic outcomes, supporting studies in liver disease, obesity, and insulin resistance.

High Purity & Research Consistency

Available as a highly purified, biologically active protein suitable for in vitro and in vivo experimental applications.

Molecular Details

Parameter	Description
CAS Number	80449-31-6
Product Name	Follistatin
Molecular Formula	C₁₈₁H₂₉₇N₅₅O₅₁S₁₀
Molecular Weight	~25,000–28,000 Da (depending on glycosylation)
Peptide Length	344 amino acids (glycoprotein)
Appearance	White to off-white lyophilized powder
Storage	–20°C, protected from light and moisture

Specifications & Packaging

Specification	Option
Purity	≥95% (SDS-PAGE / HPLC)
Form	Lyophilized protein powder
Vial Sizes	1 mg, 5 mg, 10 mg (custom packaging available)
Packaging	Sterile sealed vials, moisture-resistant, temperature-controlled
Shelf Life	12–24 months under recommended storage conditions

Applications in Research and Development

1. Muscle Growth & Myostatin Research: Used in studies targeting skeletal muscle hypertrophy, muscle wasting disorders, and sarcopenia.

2. Tissue Regeneration & Repair Studies: Supports research in liver regeneration, cardiac repair, and skeletal muscle recovery.

3. Reproductive Biology Research: Investigates FSH regulation, activin modulation, and reproductive hormone pathways.

4. Metabolic Disease & Anti-Fibrotic Research: Explores obesity, insulin resistance, and fibrosis models in preclinical studies.

5. Peptide Therapeutic Development: Serves as a template for designing myostatin inhibitors and regenerative medicine therapeutics.

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