Product Description
Product Details
1.Core Identity and Code Name
· Generic name: Retatrutide (Rivarotide)
· Category: Investigational, once-weekly subcutaneous injection medication.
2. Mechanism of action: Triple hormone receptor agonist
The core breakthrough of Retatrutide lies in its "triple agonist" mechanism, which is the fundamental difference between it and all current weight loss drugs (such as semaglutide, tirasopine). It targets three key hormone receptors simultaneously:
· GLP-1 receptor: Enhances insulin secretion, suppresses appetite, and delays gastric emptying.
· GIP receptor: Enhances the hypoglycemic effect of GLP-1 and may act independently on fat metabolism, increasing energy expenditure.
· Glucagon receptor: Strongly promotes energy consumption, increases basal metabolic rate, and directly "burns" calories.
This triple effect creates a synergistic effect of "reducing intake" + "increasing expenditure", which theoretically can achieve an unprecedented weight loss and metabolic improvement result.
3. Summary of Core Clinical Data (Based on the TRIUMPH Series of Phase III Clinical Trials)
· The weight loss effect is astonishing:
· In the 48-week "without lifestyle intervention" study, patients using the highest dose (12mg) achieved an average weight loss of 24.2%.
· More than half (about 57%) of the patients experienced a weight loss of ≥20%, and about one-third (about 32%) experienced a weight loss of ≥25%. This is the first time that a drug has achieved the milestone of an average weight loss of over 20% in a clinical trial.
· Comprehensive metabolic improvement:
· Blood sugar control: Significantly reduced blood sugar and glycosylated hemoglobin, with great potential for the treatment of type 2 diabetes.
· Lipid improvement: Reduced triglycerides, low-density lipoprotein cholesterol, etc.
· Blood pressure reduction: Significant decreases in systolic and diastolic blood pressure were observed.
· Liver fat reduction: Has a significant improvement effect on non-alcoholic fatty liver disease/hepatitis.
4. Potential indications (research direction)
· Obesity: As a chronic weight management medication.
· Type 2 diabetes: While controlling blood sugar, it brings significant weight loss benefits.
· Non-alcoholic fatty liver disease: Regarding its effect in improving liver fat and inflammation.
· Reduced risk of cardiovascular diseases: Based on its improvement of multiple risk factors such as blood pressure and blood lipids.
5. Safety and Common Side Effects
Similar to other similar drugs, the side effects are mainly related to the gastrointestinal tract and are mostly mild to moderate and temporary:
· Common side effects: nausea, diarrhea, vomiting, constipation, indigestion.
· Characteristics of side effects: Usually occur during the dose escalation period and ease as the body adapts. The three mechanisms involve the activation of glucagon receptors, which theoretically may cause a slight increase in heart rate. This effect has been monitored in clinical trials.
6. Current Status and Expectations
· Status: The key phase III clinical trials have been completed and the data have been released. We are actively preparing to submit the application for market approval to major global drug regulatory agencies (such as the FDA in the US and the NMPA in China).
· Market positioning: If approved, it will become the most effective prescription weight loss drug to date, targeting patients with moderate to severe obesity and those with metabolic complications.
· Competitive landscape: It is regarded as a "replacement" product for existing GLP-1 drugs and telotropin, competing with next-generation multiple agonists such as CagriSema from Novo Nordisk.
Company Profile
Nanjing Shuangxindashi Trading Co., Ltd. is dedicated to the production and sales of intermediates and peptides, as well as the research and development of new materials such as bodybuilding and shaping, interesting compounds, weight loss, anti-aging, digestive tract disease regulation, and immunity enhancement. We provide professional services including raw materials, resources, and customized production. We are particularly proud of our partnerships in high-quality ingredient and raw material production to meet the needs of our diverse customers.
